Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Tizanidine Oral Solution   1 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    tizanidine hydrochloride    PWD   
    sucrose (for sucrose syrup)    PWD   
    Water, distilled (for sucrose syrup)      qs to 
    potassium sorbate    PWD   
    Water, distilled (for potassium sorbate)       
    Flavoring (Tutti Frutti)        
    Citric acid monohydrate, USP    PWD   
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. Weigh out all ingredients.
2. Prepare Sucrose Syrup vehicle: In a glass mortar, mix sucrose into distilled water (labelled "for Sucrose Syrup" in ingredient list), stirring well, and qs to volume of water indicated to make Sucrose Syrup 85% (w/v).
Set Sucrose Syrup vehicle aside.
3. In a second glass mortar, add tizanidine powder and half of the Sucrose Syrup vehicle, stirring well until the solution is homogenous.
4. In a third glass mortar, add potassium sorbate and distilled water (labelled "for potassium sorbate" in ingredient list). Stir well.
5. Add potassium sorbate solution to tizanidine mixture, stirring well.
6. Add Tutti-Frutti Flavouring to tizanidine mixture. Stir well.
7. Add citric acid to tizanidine mixture. Stir well.
8. Pour into a graduated cylinder.
9. Rinse glass mortars with Sucrose Syrup vehicle and qs graduated cylinder to final volume using Sucrose Syrup vehicle.
10. Transfer to final container and label.

Notes Note that tizanidine hydrochloride 114 mg = tizanidine 100 mg.

Note that "sucrose, crystal or fine granulated" was the grade of sucrose chosen.

Packaging: 100 mL Amber Glass Bottle

Auxiliary Labels: Can be stored at room temperature or refrigerated
  Shake Well

Storage/Expiry:Refrigerator or Room Temperature: 70 days

Last Date Revised: 19-Jan-21

References:Gobetti C, Balsan ME, Ayres MV, de Almeida SHO, de Saldanha Simon E, Wingert NR, et al. Development and Stability Control of Pediatric Oral Tizanidine Hydrochloride Formulations for Hospital Use. AAPS PharmSciTech. 2020 Jul 29;21(6):210. Abstract available from: https://pubmed.ncbi.nlm.nih.gov/32729029/

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   6-Dec-2021         


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