Recipe - Compounding Worksheet
Unauthorized distribution, copying or disclosure prohibited.
These recipes are intended for use by the pharmacy manufacturing departments only.
Topotecan oral solution   1 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    topotecan (powder for reconstitution)  4 mg  VIAL   
    Water, sterile        
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: Refer to the AHS Hazardous Medication Handling Guide for more information.

1. Per topotecan package insert, reconstitute each vial with sterile water for a final concentration of 1 mg/mL.
2. After reconstitution of vial, gently mix solution.
3. Transfer solution from each vial into an amber bottle.
4. Add a bottle adapter for oral syringe use.

Notes THIS FORMULATION IS NOT BASED ON LITERATURE, but is from unpublished data, historical use, or physician/pharmacy experience.
HOWEVER, stability and sterility are data based upon published literature for reconstituted injectable product. (Patel, 1998)

Packaging:  Amber Plastic Bottle

Auxiliary Labels: CHEMOTHERAPY Dispose of Properly
  Cytotoxic
  Hazardous medication - use safe handling precautions
  KNOWN Hazard Medication - Follow PPE Guide
  ORAL USE ONLY
  Protect From Light
  Refrigerate

Storage/Expiry:Refrigerator or Room Temperature: 28 days

Last Date Revised: 11-May-21

References:Topotecan 1 mg/mL Oral Solution. Standard Formulations Michigan Pharmacists Association. Ann Arbor, MI: University of Michigan College of Pharmacy; 2020. Updated: 2013 April. Accessed: 2021-04-19. Available from: https://www.mipedscompounds.org/sites/default/files/standard-formulations/Topotecan.pdf

Patel K, Craig SB, McBride MG, Palepu NR. Microbial inhibitory properties and stability of topotecan hydrochloride injection. Am J Health Syst Pharm. 1998 Aug1;55(15):1584-7. PubMed PMID: 9706184.

Vutla, Nagarupa (Accord Healthcare Inc.). RE: topotecan osmolality [Email]. Message to: Kristina Haagsma (Alberta Health Services, Edmonton, AB). 2020 April 20. [cited 2021-04-20].

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   29-Nov-2021         


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