Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Ambrisentan Oral Suspension   1 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    ambrisentan  5 mg  TAB   
    glycerin  100%  PO SOLN   
    Ora-Plus®    SYRUP   
    Ora-Sweet® vehicle      qs to final volume 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: HAZARDOUS - Reproductive
Refer to the AHS Hazardous Medication Handling Guide for more information

1. In a glass mortar, crush tablets and triturate to a fine powder.
2. Add 5 mL glycerin and mix.
3. Gradually add approximately 10 mL of Ora-Plus to continue to levigate mixture.
4. Pour into a graduated cylinder.
5. Rinse mortar and pestle with remaining Ora-Plus.
6. Qs to final volume with Oral-Sweet
7. Transfer to final container and label.

Packaging:  Amber Plastic or Glass Bottle

Auxiliary Labels: Can be stored at room temperature or refrigerated
  HAZARD: Reproductive Risk If Potential to Conceive, Pregnant or Breastfeeding FOLLOW PPE Guide
  Hazardous medication - use safe handling precautions
  Protect From Light
  Shake Well

Storage/Expiry:Refrigerator or Room Temperature: 90 days

Last Date Revised: 27-Aug-21

References:Cramer J, Bevry M, Handler S, Tillman K, Abourashed EA. Stability Determination of an Extemporaneously Compounded Ambrisentan Suspension by High Performance Liquid Chromatography Analysis. J Pediatr Pharmacol Ther. 2021;26(3):265-270. doi: 10.5863/1551-6776-26.3.265. Epub 2021 Mar 31. PMID: 33833628; PMCID: PMC8021248. https://pubmed.ncbi.nlm.nih.gov/33833628/

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   6-Dec-2021         


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