Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Aprepitant Oral Suspension    20 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    aprepitant  125 mg  CAP   
    Ora-Plus® / Ora-Sweet®  1:1  SYRUP  qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. Empty contents of capsules into a mortar and triturate to a fine powder. May take 10 to 15 minutes to get powder into a fine consistency or alternatively triturate capsules and soak in 3 to 5 mL of water. Do not soak capsule contents in Ora-Plus® and Ora-Sweet® before triturating.
2. Mix Ora-Plus® and Ora-Sweet® together (1:1) to make vehicle.
3. Gradually levigate powder with vehicle until a liquid is formed.
4. Pour into a graduated cylinder.
5. Rinse mortar and qs to final volume with vehicle.
6. Transfer to final container and label.

Notes Recipe can also be prepared with aprepitant 80 mg capsules.

Ora-Blend® can be used instead of Ora-Plus® /Ora-Sweet® (1:1).

Can be packaged in amber glass bottles or polyethylene terephthalate (PET) plastic containers.

Packaging: 100 mL Amber Glass Bottle

Auxiliary Labels: Refrigerate
  Shake Well

Storage/Expiry:Refrigerator: 90 days

Last Date Revised: 6-Jun-18

References:Dupuis LL. Lingertat-Walsh K. Walker SE. Stability of an extemporaneous oral liquid aprepitant formulation. Support Care Cancer 2009; 17:701-706.

Formulations: Aprepitant 20-mg/mL oral liquid. International Journal of Pharmaceutical Compounding 2009; 13(2):153.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist

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