Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Ketoconazole Oral Suspension   20 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    ketoconazole  200 mg  TAB   
    Ora-Plus® / Ora-Sweet®  1:1  SYRUP  qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. In a mortar, crush tablets and triturate to a fine powder.
2. Mix Ora-Plus® and Ora-Sweet® together (1:1) to make vehicle.
3. Gradually levigate powder with vehicle until a liquid is formed.
4. Pour into a graduated cylinder.
5. Rinse mortar and qs to final volume with vehicle.
6. Transfer to final container and label.

Notes Ketoconazole tablets are Non-Formulary with a Therapeutic Interchange.
Refer to Ketoconazole tablets in AHS Provincial Formulary.

May substitute Ora-Plus® / Ora-Sweet® (1:1) with any of the following vehicles:
- Ora-Plus® / Ora-Sweet SF® (1:1)
- Ora-Blend®
- Ora-Blend SF®
- Cherry Syrup; please note recipe requires the ready-to-use cherry syrup and NOT the cherry syrup concentrate. If your site uses the concentrate, it MUST be diluted before using in the recipe.

Ora-Sweet SF® and Ora-Blend SF® should not be used in neonates less than or equal to 28 days corrected age.

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Can be stored at room temperature or refrigerated
  Protect From Light
  Shake Well

Storage/Expiry:Refrigerator or Room Temperature: 60 days

Last Date Revised: 24-Jan-14

References:Allen L, Erickson M. Stability of ketoconazole, metolazone, metronidazole, procainamide hydrochloride, and spironolactone in extemporaneously compounded oral liquids. Am J Health-Syst Pharm 1996; 53:2073-2078.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   6-Dec-2021         


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