Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Mercaptopurine Oral Suspension   50 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    mercaptopurine  50 mg  TAB   
    ascorbic acid  500 mg  TAB   
    Water, sterile        
    Simple syrup        
    Cherry syrup      qs to  
Recipe Total Quantity:
Final Quantity Desired: mL

Refer to the AHS Hazardous Medication Handling Guide for more information.

1. In a mortar, crush mercaptopurine and vitamin C tablets and levigate with water to form a smooth paste.
2. Add the simple syrup with continuous mixing.
3. Pour into a measuring container.
4. Rinse the mortar and qs to final volume with cherry syrup. Mix well.
5. Transfer to final container and label.

Notes Please note that this recipe uses the ready-to-use cherry syrup, NOT the cherry syrup concentrate. If your site uses the concentrate, it MUST be diluted before using in the recipe.

Ascorbic Acid (vitamin C) powder can be used instead of Vitamin C tablets.

Regular non-chewable tablets of Vitamin C can be used instead of the chewable tablets. Color of final product may differ depending upon the excipients in the tablets.

May also dispense in oral amber plastic syringes.

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Antineoplastic Agent
  CHEMOTHERAPY Dispose of Properly
  Hazardous medication - use safe handling precautions
  Note Strength
  Protect From Light
  Shake Well
  Store at Room Temperature

Storage/Expiry:Room Temperature: 11 weeks

Last Date Revised: 17-May-18

References: AHS Hazardous Medication Handling information available on Insite:

Alliabadi HM. Romanick M. Desai S. Lavasanifar A. Effect of buffer and antioxidant on stability of a mercaptopurine suspension. Am J Health-Syst Pharm 2008; 65:441-447.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist

This content is provided for general information purposes only. It is not intended to replace consultations with a health care professional or to provide medical advice, diagnosis or treatment. Always seek the advice of a physician or other qualified health care provider with any medical or health questions. Alberta Health Services accepts no responsibility for any modification or redistribution of this document and is not liable for any actions taken by individuals based on the information provided, or for any inaccuracies, errors, or omissions in the information in this document. These recipes are to be used as a reference and are not intended to be master formulation records. Not all recipes may be compliant with NAPRA or other standards.