Recipe - Compounding Worksheet
Unauthorized distribution, copying or disclosure prohibited.
These recipes are intended for use by the pharmacy manufacturing departments only.
metroNIDAZOLE Oral Suspension    50 mg/mL *Note Strength*
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    metronidazole  250 mg  TAB   
    Water, sterile       to wet tablets 
    Ora-Plus® / Ora-Sweet®  1:1  SYRUP  qs to  
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. Place tablets in mortar and soak with water. Allow mixture to sit for a few minutes until tablets soften.
2. Levigate above mixture into a smooth paste.
3. Mix Ora-Plus® and Ora-Sweet® together (1:1) to make vehicle.
4. Gradually levigate paste with vehicle until a liquid is formed.
5. Pour into a graduated cylinder.
6. Rinse mortar and qs to final volume with vehicle.
7. Transfer to final container and label.

Notes May substitute Ora-Plus® / Ora-Sweet® (1:1) with any of the following vehicles:
- Ora-Plus® / Ora-Sweet SF® (1:1)
- Ora-Blend®
- Ora-Blend SF®
- Cherry Syrup; please note recipe requires the ready-to-use cherry syrup and NOT the cherry syrup concentrate. If your site uses the concentrate, it MUST be diluted before using in the recipe.

Ora-Sweet SF® and Ora-Blend SF® should not be used in neonates less than or equal to 28 days corrected age.

If the tablets are not available, other forms/ strengths of metronidazole ( i.e. 500 mg capsules) in the appropriate amount can be used to prepare this suspension.
- Empty contents of capsule and levigate with water and syrup.
- These products are non-formulary and should only be used when the 250 mg tablets are not available.

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Can be stored at room temperature or refrigerated
  Note Strength
  Protect From Light
  Shake Well

Storage/Expiry:Refrigerator or Room Temperature: 60 days

Last Date Revised: 30-May-13

References:Allen LV, Erickson MA. Stability of ketoconazole, metolazone, metronidazole, procainamide hydrochloride, and spironolactone in extemporaneously compounded oral liquids. Am J Health-Syst Pharm 1996 (Sep 1); 53:2073-2078.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist

This content is provided for general information purposes only. It is not intended to replace consultations with a health care professional or to provide medical advice, diagnosis or treatment. Always seek the advice of a physician or other qualified health care provider with any medical or health questions. Alberta Health Services accepts no responsibility for any modification or redistribution of this document and is not liable for any actions taken by individuals based on the information provided, or for any inaccuracies, errors, or omissions in the information in this document. These recipes are to be used as a reference and are not intended to be master formulation records. Not all recipes may be compliant with NAPRA or other standards.