Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
metroNIDAZOLE Oral Suspension    50 mg/mL *Note Strength*
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    metronidazole  250 mg  TAB   
    Water, sterile       to wet tablets 
    Ora-Plus® / Ora-Sweet®  1:1  SYRUP  qs to  
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. Place tablets in mortar and soak with water. Allow mixture to sit for a few minutes until tablets soften.
2. Levigate above mixture into a smooth paste.
3. Mix Ora-Plus® and Ora-Sweet® together (1:1) to make vehicle.
4. Gradually levigate paste with vehicle until a liquid is formed.
5. Pour into a graduated cylinder.
6. Rinse mortar and qs to final volume with vehicle.
7. Transfer to final container and label.

Notes May substitute Ora-Plus® / Ora-Sweet® (1:1) with any of the following vehicles:
- Ora-Plus® / Ora-Sweet SF® (1:1)
- Ora-Blend®
- Ora-Blend SF®
- Cherry Syrup; please note recipe requires the ready-to-use cherry syrup and NOT the cherry syrup concentrate. If your site uses the concentrate, it MUST be diluted before using in the recipe.

Ora-Sweet SF® and Ora-Blend SF® should not be used in neonates less than or equal to 28 days corrected age.

NOTE:
If the tablets are not available, other forms/ strengths of metronidazole ( i.e. 500 mg capsules) in the appropriate amount can be used to prepare this suspension.
- Empty contents of capsule and levigate with water and syrup.
- These products are non-formulary and should only be used when the 250 mg tablets are not available.

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Can be stored at room temperature or refrigerated
  Note Strength
  Protect From Light
  Shake Well

Storage/Expiry:Refrigerator or Room Temperature: 60 days

Last Date Revised: 30-May-13

References:Allen LV, Erickson MA. Stability of ketoconazole, metolazone, metronidazole, procainamide hydrochloride, and spironolactone in extemporaneously compounded oral liquids. Am J Health-Syst Pharm 1996 (Sep 1); 53:2073-2078.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   6-Dec-2021         


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