Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Mexiletine Oral Suspension   10 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    mexiletine  200 mg  CAP   
    Sorbitol 70%      qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. Empty contents of capsules into a mortar and triturate to a fine powder.
2. Gradually levigate powder with vehicle until a liquid is formed.
3. Pour into a graduated cylinder.
4. Rinse mortar and qs to final volume with vehicle.
5. Transfer to final container and label.

Notes Sterile water may be used instead of Sorbitol 70%, but stability is different (see Storage/Expiry Section).

Refrigerated storage is preferred.

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Refrigerate
  Shake Well

Storage/Expiry:Refrigerator: 28 days (with Sorbitol 70%)
  Refrigerator: 91 days (with Sterile Water)
  Room Temperature: 14 days (with Sorbitol 70%)
  Room Temperature: 70 days (with Sterile Water)

Last Date Revised: 8-Jun-11

References:Nahata MC. Morosco RS. Hipple TF. Stability of mexiletine in two extemporanous liquid formulations stored under refrigeration and at room temperature. J Am Pharm Assoc 2000; 40:257-259.
 
Nahata MC, Pai VB, Hipple TF. Pediatric drug formulations. 5th ed. Cincinnati, OH: Harvey Whitney Books Company; 2003.
 
Nahata MC, Pai VB, Hipple TF. Pediatric drug formulations. 5th ed. Cincinnati, OH: Harvey Whitney Books Company; 2003.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   6-Dec-2021         


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