Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Mycophenolate Mofetil Oral Suspension - Sugar Free   100 mg/mL *Note Strength*
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    mycophenolate mofetil  250 mg  CAP   
    aspartame     PWD   
    Cherry flavouring concentrate       
    Ora-PlusŪ    SYRUP  qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: HAZARDOUS - Potential
Refer to the AHS Hazardous Medication Handling Guide for more information.

1. Mix Ora-PlusŪ, aspartame and cherry flavoring to make vehicle.
2. Empty contents of capsules into a mortar and triturate to a fine powder.
3. Wet the powder with a small amount vehicle (made in Step 1) to make a paste.
4. Gradually levigate paste with vehicle until a liquid is formed.
5. Pour into a graduated cylinder.
6. Rinse mortar and qs to final volume with vehicle.
7. Transfer to final container and label.

Notes A commercial 200 mg/mL oral formulation is available. Strength of compounded formulation is different than the commercial preparation.
This strength is non-formulary.
Refer to Mycophenolate suspension in AHS Provincial Formulary.

This recipe should only be prepared when the commercial product is not suitable for the patient.

This formulation contains aspartame.

Refrigerated storage is preferred.

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Hazardous medication - use safe handling precautions
  Note Strength
  Refrigerate
  Shake Well

Storage/Expiry:Refrigerator: 120 days (preferred storage)
  Room Temperature: 28 days (cherry flavor odor becomes a musty odor if preparation is stored at room temperature for 120 days, but mycophenolate is stable for 120 days at room temperature)

Last Date Revised: 2-Dec-19

References: AHS Hazardous Medication Handling information available on Insite: http://insite.albertahealthservices.ca/17382.asp

Swenson CF, et al. Stability of mycophenolate mofetil in an extemporaneously compounded sugar-free oral liquid. Am J Health-Syst Pharm 1999; 56:2224-2226.
 
Nahata MC, Pai VB, Hipple TF. Pediatric drug formulations. 5th ed. Cincinnati, OH: Harvey Whitney Books Company; 2003.
 
Nahata MC, Pai VB, Hipple TF. Pediatric drug formulations. 5th ed. Cincinnati, OH: Harvey Whitney Books Company; 2003.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   6-Dec-2021         


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