Recipe - Compounding Worksheet
Unauthorized distribution, copying or disclosure prohibited.
These recipes are intended for use by the pharmacy manufacturing departments only.
Sotalol Oral Suspension   5 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    sotalol  80 mg  TAB   
    Ora-Plus® / Ora-Sweet®  1:1  SYRUP  qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. In a mortar, crush tablets and triturate to a fine powder.
2. Mix Ora-Plus® and Ora-Sweet® together (1:1) to make vehicle.
3. Gradually levigate powder with vehicle until a liquid is formed.
4. Pour into a graduated cylinder.
5. Rinse mortar and qs to final volume with vehicle.
6. Transfer to final container and label.

Notes May substitute Ora-Plus® / Ora-Sweet® (1:1) with any of the following vehicles:
- Ora-Plus® / Ora-Sweet SF® (1:1)
- Ora-Blend®
- Ora-Blend SF®
- Simple Syrup/ Methylcellulose 1% solution preserved with Sodium Benzoate (1:2.5)
- Methylcellulose 1% solution/ Simple Syrup (1:9)

Ora-Sweet SF® and Ora-Blend SF® should not be used in neonates less than or equal to 28 days corrected age.

Refrigerated storage is preferred.

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Can be stored at room temperature or refrigerated
  Shake Well

Storage/Expiry:Refrigerator or Room Temperature: 12 weeks

Last Date Revised: 21-Nov-11

References:Allen Loyd V Jr. Sotalol hydrochloride 5 mg/mL oral suspension. International Journal of Pharmaceutical Compounding 2011 (Sept/Oct); 15(5):425.

Sidhorn MB. Rivera N. Almoazen H. Taft DR. Kirschenbaum HL. Stability of sotalol hydrochloride in extemporaneously prepared oral suspension formulations. International Journal of Pharmaceutical Compounding 2005 (Sept/Oct); 9(5): 402-406.

Nahata MC, Morosco RS. Stability of sotalol in two liquid formulations at two temperatures. Annals of Pharmacotherapy 2003; 37:506-509.
 
Nahata MC, Pai VB, Hipple TF. Pediatric drug formulations. 5th ed. Cincinnati, OH: Harvey Whitney Books Company; 2003.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   6-Dec-2021         


This content is provided for general information purposes only. It is not intended to replace consultations with a health care professional or to provide medical advice, diagnosis or treatment. Always seek the advice of a physician or other qualified health care provider with any medical or health questions. Alberta Health Services accepts no responsibility for any modification or redistribution of this document and is not liable for any actions taken by individuals based on the information provided, or for any inaccuracies, errors, or omissions in the information in this document. These recipes are to be used as a reference and are not intended to be master formulation records. Not all recipes may be compliant with NAPRA or other standards.