Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Sotalol Oral Suspension   5 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    sotalol  80 mg  TAB   
    Ora-Plus® / Ora-Sweet®  1:1  SYRUP  qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. In a mortar, crush tablets and triturate to a fine powder.
2. Mix Ora-Plus® and Ora-Sweet® together (1:1) to make vehicle.
3. Gradually levigate powder with vehicle until a liquid is formed.
4. Pour into a graduated cylinder.
5. Rinse mortar and qs to final volume with vehicle.
6. Transfer to final container and label.

Notes May substitute Ora-Plus® / Ora-Sweet® (1:1) with any of the following vehicles:
- Ora-Plus® / Ora-Sweet SF® (1:1)
- Ora-Blend®
- Ora-Blend SF®
- Simple Syrup/ Methylcellulose 1% solution preserved with Sodium Benzoate (1:2.5)
- Methylcellulose 1% solution/ Simple Syrup (1:9)

Ora-Sweet SF® and Ora-Blend SF® should not be used in neonates less than or equal to 28 days corrected age.

Refrigerated storage is preferred.

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Can be stored at room temperature or refrigerated
  Shake Well

Storage/Expiry:Refrigerator or Room Temperature: 12 weeks

Last Date Revised: 21-Nov-11

References:Allen Loyd V Jr. Sotalol hydrochloride 5 mg/mL oral suspension. International Journal of Pharmaceutical Compounding 2011 (Sept/Oct); 15(5):425.

Sidhorn MB. Rivera N. Almoazen H. Taft DR. Kirschenbaum HL. Stability of sotalol hydrochloride in extemporaneously prepared oral suspension formulations. International Journal of Pharmaceutical Compounding 2005 (Sept/Oct); 9(5): 402-406.

Nahata MC, Morosco RS. Stability of sotalol in two liquid formulations at two temperatures. Annals of Pharmacotherapy 2003; 37:506-509.
Nahata MC, Pai VB, Hipple TF. Pediatric drug formulations. 5th ed. Cincinnati, OH: Harvey Whitney Books Company; 2003.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist

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