Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Spironolactone/ Hydrochlorothiazide Oral Suspension   5 mg/5 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    spironolactone - hydrochlorothiazide  25 mg - 25 mg  TAB   
    Ora-Plus® / Ora-Sweet®  1:1  SYRUP  qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: HAZARDOUS - Potential
Refer to the AHS Hazardous Medication Handling Guide for more information.

1. In a mortar, crush tablets and triturate to a fine powder.
2. Mix Ora-Plus® and Ora-Sweet® together (1:1) to make vehicle.
3. Gradually levigate powder with vehicle until a liquid is formed.
4. Pour into a graduated cylinder.
5. Rinse mortar and qs to final volume with vehicle.
6. Transfer to final container and label.

Notes If tablets are difficult to crush:
1. Place tablets in mortar and soak in a small amount of water (approximately 5 mL) for 5 to 10 minutes.
2. Once tablets are sufficiently softened/ dissolved, grind tablets to form a smooth paste.
3. Follow remaining steps in directions section.

May substitute Ora-Plus® / Ora-Sweet® (1:1) with any of the following vehicles:
- Ora-Plus® / Ora-Sweet SF® (1:1)
- Ora-Blend®
- Ora-Blend SF®
- Cherry Syrup; please note recipe requires the ready-to-use cherry syrup and NOT the cherry syrup concentrate. If your site uses the concentrate, it MUST be diluted before using in the recipe.

Ora-Sweet SF® and Ora-Blend SF® should not be used in neonates less than or equal to 28 days corrected age.

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Can be stored at room temperature or refrigerated
  Hazardous medication - use safe handling precautions
  Protect From Light
  Shake Well

Storage/Expiry:Refrigerator or Room Temperature: 60 days

Last Date Revised: 2-Dec-19

References: AHS Hazardous Medication Handling information available on Insite: http://insite.albertahealthservices.ca/17382.asp

SickKids Compounding Service [online recipes]. Toronto, ON: The Hospital for Sick Children. C1999 – [current date]. Available from: http://www.sickkids.ca/Pharmacy/Compounding-Service/index.html

Allen LV, Erickson MA. Stability of labetalol hydrochloride, metoprolol tartrate, verapamil hydrochloride, and spironolactone with hydrochlorothiazide in extemporaneously compounded oral liquids. Am J Health-Syst Pharm 1996; 53(19):2304-2309

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   6-Dec-2021         


This content is provided for general information purposes only. It is not intended to replace consultations with a health care professional or to provide medical advice, diagnosis or treatment. Always seek the advice of a physician or other qualified health care provider with any medical or health questions. Alberta Health Services accepts no responsibility for any modification or redistribution of this document and is not liable for any actions taken by individuals based on the information provided, or for any inaccuracies, errors, or omissions in the information in this document. These recipes are to be used as a reference and are not intended to be master formulation records. Not all recipes may be compliant with NAPRA or other standards.