RENAL FAILURE
|
- This information will be included if any dosage adjustments are required, or if there is information that adjustments are not needed for renal failure.
- The information will be from a variety of renal drug references, including Drug Prescribing in Renal Failure, Renal Drug Book, product monographs, journal articles, or other sources.
|
 |
|
Monograph TEMPLATE
Generic drug name
References
|
- Important administration information specific to adults will be highlighted in this section.
- Extravasation/ infiltration information will be included here if applicable. For definitions of these terms, refer to the Parenteral Manual Definitions document.
- Information is from the zone parenteral monographs, product monographs, or other sources.
- Only applicable routes of administration will be displayed below.
|
|
Back To Top  |
DIRECT IV - Adults
|
- Administration information will be from product monographs, Lexicomp, journal articles, etc.
- If applicable, this information was derived from the administration guidelines from the zone parenteral monographs.
|
|
|
| Back To Top |
INTERMITTENT IV INFUSION - Adults
|
- Administration information will be from product monographs, Lexicomp, journal articles, etc.
- If applicable, this information was derived from the administration guidelines from the zone parenteral monographs.
- If applicable, provincial standard concentrations will be included.
|
|
|
| Back To Top |
CONTINUOUS IV INFUSION - Adults
|
- Administration information will be from product monographs, Lexicomp, journal articles, etc.
- If applicable, this information was derived from the administration guidelines from the zone parenteral monographs.
- If applicable, provincial standard concentrations will be included.
|
|
|
| Back To Top |
SUBCUTANEOUS INJECTION - Adults
|
- Administration information will be from product monographs, Lexicomp, journal articles, etc.
- If applicable, this information was derived from the administration guidelines from the zone parenteral monographs.
|
|
|
| Back To Top |
SUBCUTANEOUS INFUSION - Adults
|
- Administration information will be from product monographs, Lexicomp, journal articles, etc.
- If applicable, this information was derived from the administration guidelines from the zone parenteral monographs.
- If applicable, provincial standard concentrations will be included.
|
|
|
| Back To Top |
INTRAMUSCULAR INJECTION - Adults
|
- Administration information will be from product monographs, Lexicomp, journal articles, etc.
- If applicable, this information was derived from the administration guidelines from the zone parenteral monographs.
|
|
|
| Back To Top |
OTHER - Adults
|
- Administration information will be from product monographs, Lexicomp, journal articles, etc.
- If applicable, this information was derived from the administration guidelines from the zone parenteral monographs.
- If applicable, provincial standard concentrations will be included.
|
|
|
| Back To Top |
(References)
|
- Important information about the product (e.g. incompatibility with container types) will be highlighted in this section.
|
|
|
PRODUCT DESCRIPTION - This information will include the available concentrations and formulations of the drug as well as the storage conditions.
- Vial ingredients/excipients that may be problematic to the patient will be included here (e.g. propylene glycol in neonates).
- The information will generally be from the product monograph.
|
|
RECONSTITUTION - Instructions will be available if required, including the final concentration and stability of the reconstituted solution.
- The information will generally be from the product monograph.
|
|
IV SOLUTION STABILITY
(Please note that stability information does not apply to parenteral products mixed by
Pharmacy).
- Stability information on reconstituted and diluted IV solutions will generally be from the manufacturer's recommendations, and will be for staff mixing the infusions in patient-care areas.
- It does NOT include sterile products prepared by the Pharmacy department.
|
| Back To Top |
- The parenteral monographs are not meant to be a comprehensive source of compatibility information. For the most current and complete listing of compatibility data, please consult
Micromedex
or Lexicomp.
- Drug IV compatibility is dependent on a number of factors including tested concentrations, diluents and storage conditions. See monograph template for more detailed information.
- Compatibility of MORE THAN TWO drugs in the same line or container may NOT be inferred from any information presented in the following intravenous compatibility charts.
(References)
|
- This is NOT a complete listing of all compatibility data but is meant as a quick reference.
- Data is taken from Trissel'sTM 2 IV Compatibility (in Micromedex).
- Sites may consult and utilize other resources for compatibility information but this information will not be included on the monographs.
- Y-site compatibility means that two separate drug infusions are compatible when infused through the same IV line. It is dependent on a number of factors:
- IV solution/diluent:
- Data only applies to both drugs mixed in the same tested IV solutions. Exceptions will be noted in the Y-site compatibility table on the monograph.
- Tested concentrations:
- Data only applies to up to and including the tested drug concentrations.
- Interpreting information in the monograph Y-site compatibility tables:
- Compatibility information applies only to both drugs mixed separately in the same type of IV solution unless indicated otherwise. If the parenteral monograph indicates that ampicillin is compatible with furosemide in NS, it means that both infusions must be mixed in NS separately.
- The separate IV lines can then be connected, and both infusions run through the same line without risk of precipitation.
- This chart is based on studies in which usual concentrations were used for the diluents specified. Contact your pharmacist if you have questions regarding more concentrated solutions (e.g. in fluid-restricted patients).
- EXAMPLE: Drug X, at concentrations up to X mg/mL, is compatible with the following drugs at usual administration concentrations mixed in D5W, NS, and D5-1/2NS (unless indicated):
|
| amikacin - mix in NS or D5W (both drugs may be mixed in either solution) |
|
amphotericin B |
|
atracurium |
|
atropine |
|
calcium chloride |
|
|
calcium gluconate |
|
cefazolin - mix in NS only (both drugs must be mixed in this solution) |
|
ceftriaxone |
|
cefuroxime |
|
|
doxycycline |
|
epinephrine |
|
erythromycin |
|
imipenem-cilastatin in NS & drug X in D5W (will indicate if drugs must be mixed in specific solutions) |
|
metronidazole premixed bags |
|
|
- This is a documented physical interaction (precipitation, color change) or chemical interaction (drug degradation, drug interaction). These two drugs should NOT be infused through the same intravenous site.
- Where there are conflicting reports, factors such as concentration or additives, intravenous solutions used, pH of the solution, and percentage of drug degradation are considered, and a conclusion is made.
- Where no compatibility data is available (from all sources), avoid infusing the drugs via Y-site.
- EXAMPLE: Drug X is INCOMPATIBLE with the following drugs:
|
|
|
|
|
|
cefazolin in D5W (will indicate incompatibility in specific solutions) |
|
digoxin |
|
|
| Back To Top |